The aim of present research work is to formulate and evaluate bilayer tablets of Salbutamol Sulphate with extended release. Salbutamol is a rapidly acting and rapidly eliminated bronchodilator agent. Salbutamol starts acting within 15-30 min or less after administration of tablet and its action lasts for 3 hrs. To provide extended release, polymers used are HPMC K100M, HPMC K4M, HPMC K15M and immediate release system is prepared by using different disintegrating agent like SSG, CMC, MCC by wet granulation method. 32 factorial design was chosen. Prepared batches evaluated for precompression parameters and process parameters like hardness, friability, morphology, drug content and in vitro drug release profile. Effect of polymers and disintegrants in two different layers affect in vitro drug release. It was found that the Salbutamol sulphate release rate increase with decrease amount of polymers and increase in amount of disintegrants. It can be concluded that Bilayer tablet is simple, cost effective and yields robust, stable tablets as a optimized formulation in research work.
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